Keap1 modification and nuclear accumulation in response to S-nitrosocysteine
نویسندگان
چکیده
منابع مشابه
PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function.
PALB2/FANCN is mutated in breast and pancreatic cancers and Fanconi anemia (FA). It controls the intranuclear localization, stability, and DNA repair function of BRCA2 and links BRCA1 and BRCA2 in DNA homologous recombination repair and breast cancer suppression. Here, we show that PALB2 directly interacts with KEAP1, an oxidative stress sensor that binds and represses the master antioxidant tr...
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2008
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2007.10.055